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VonFrey

Summary of Core Facilities

Cognitive Function

Object Recognition

Object Placement

Social Discrimination Memory

Spontaneous Alternation

• Morris Water Maze

• Sensorimotor gaiting

• Radial Arm Maze

• Conditioned Taste Aversion

Labyrinth Maze

Affective / Emotional Behaviors

Social Interaction

Social Preference

Transmission of Food Preferences

Reproductive and mating behavior

Open Field

Marble Burying

Elevated Plus Maze

• Light/Dark Box

• Acoustic Startle

Porsolt (Forced Swim) Test

Maternal behavior

Novelty Supression of Feeding

Anhedonia

 

Tests of Analgesia

Von Frey

Cold Tail Flick

 

Sensorimotor Function

Open Field

Rotarod

Grip Strength

• Gait analysis and toe spread

Balance Beam

• Visual Placing

• Visual Cliff

• Pupil dilation

Tape removal test

 

Other

Functional Observation Battery

Estrous Cycle Staging

• Behavioral Tracking software

• Conditioned Place Preference

• Grooming

• Stereotypies

Developmental milestones (pups)

Homing (pups)

Play (juvenile)

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Von Frey

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Von Frey filaments can be used to determine tactile sensitivity using application of ascending force intensities. Any glabrous area can be probed, but most commontly the plantar surface of the hind paw is used. Each filament is designed to produce a given force (in g) precisely upon buckling. Thus, the minimum force to evoke a withdrawal response and the tactile threshold can be determined. Each filament is applied 10 times with 5-30 s random intervals. A reaction to a given stimulus was defined as rapid withdrawal of the hind paw when stimuli are applied and the number of responses to each stimulus intensity is determined. Tactile threshold is generally defined as a withdrawal response in 8 of the 10 trials to a given stimulus intensity. A higher number responses across stimulus intensities results in a lower tactile threshold and is interpreted and increased tactile sensitivity.

Lambert, G.A., Mallos, G., and Zagami, A.S., Von Frey's hairs - a review of their technology and use - a novel automated von Frey device for improved testing for hyperalgesia. Journal of Neuroscience Methods, 2009. 177(2): p. 420-426.

Chaplan, S.R., et al., Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods, 1994. 53(1): p. 55-63.

Arguis, M.J., et al., Contralateral Neuropathic Pain Following a Surgical Model of Unilateral Nerve Injury in Rats. Regional Anesthesia and Pain Medicine. 33(3): p. 211-216.

Chacur, M., et al., A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain, 2001. 94(3): p. 231-244.

Johansson, R.S., Vallbo, B., and Westling, G., Thresholds of mechanosensitive afferents in the human hand as measured with von Frey hairs. Brain Research, 1980. 184(2): p. 343-35